Control of the <i>SOST</i> Bone Enhancer by PTH Using MEF2 Transcription Factors

Abstract

These data strongly suggest that SOST expression in osteocytes of adult bone and its inhibition by PTH is mediated by MEF2A, C, and D transcription factors controlling the SOST bone enhancer. Hence, MEF2s are implicated in the regulation of adult bone mass.