Experimental myasthenia: Lack of correlation between the autoantibody titer and the reduction of acetylcholine‐controlled ionic channels measured at functioning endplates

Abstract

Abstract Inbred rats with experimental autoimmune myasthenia gravis (EAMG) show no correlation between the serum autoantibody (Antiacetylcholine receptor antibody) concentration and the reduction of endplate acetylcholine‐controlled ionic channels, as measured by a novel electrophysiological technique termed quantitative ionophoresis . This has implications for attempts to explain the well‐documented lack of correlation between the autoantibody titer and the clinical severity of myasthenia gravis (MG).