Australian Journal of Chemistry · 1972 · 19 citations · 0 references
Life SciencesNeurosciencePharmacologyNeurochemistryNeuropharmacologyStructure-activity RelationshipsGabaergic PharmacologyGabaergic SignalingNeurochemical PharmacologyNeurotransmissionNeurotransmitter SystemsSynaptic TransmissionGaba AgonistsInhibitory NeurotransmissionInhibitory Synaptic TransmissionInhibitory TransmissionIsoxazole ChemistryIsoxazole SynthesisNucleophilic ReactivityPostsynaptic Inhibition
We report the preparation of 4-aminotetrolic acid (4-aminobut-2-ynoic acid) and some of its N-substituted derivatives as simple conformationally restricted analogues of the inhibitory synaptic transmitter, y-aminobutyric acid (GABA).