Dermatology · 2009 · 28 citations · 0 references
MedicineDermatologyOncologyCancer PharmacologyChemotherapyCutaneous OncologyDermal ToxicityDermatologic Toxicity ManagementDrug-induced Skin ReactionsMalignant NeoplasmsMitotic InhibitorsSkin IrritationAntimitotic ChemotherapyAntineoplastic Drug AdministrationAntineoplastic Drug TherapyChemotherapeutic ToxicologyChemotherapy-induced Dermatologic ToxicityCutaneous Immune ResponseMedication-induced Erythema
Chemotherapy-induced acral erythema is a peculiar localized cutaneous response to several chemotherapeutic agents, mostly antimetabolites. Taxol is a recently developed antineoplastic drug that acts on the mitotic spindle and does not interfere with nucleic acid synthesis. We describe the first case of taxol-induced acral erythema and report on additional data concerning the pathogenesis of this kind of toxic eruptions.