SYNTHESIS AND EFFECT OF GAMMA RADIATION ON SOME SULFUR CONTAINING 3-SUBSTITUTED-4-OXO-2,4,5,6,7,8-HEXAHYDROBENZO [b]THIENO-[2,3-d]PYRIMIDINES OF BIOLOGICAL INTEREST

Abstract

Abstract Condensation of 4-oxo-3,4,5,6,7,8-hexahydrobenzo [b]thieno [2,3-d]-pyrimidine (I) with allyl bromide or ethyl chloroacetate gave (IIa, b). Interaction of the ester derivative IIb with hydrazine hydrate furnished the hydrazide derivative III which was used as starting material for the synthesis of pyrazoles, oxadiazoles, thiosemicarbazide and hydrazone derivatives IV, V, VI, VII, VIII, IX, and XI respectively. Cyclodehydration of thiosemicarbazide derivative IX with sodium hydroxide resulted in the formation of N-phenyl-mercaptotriazole derivative X. The thiazolidenones (XIIa–d) were obtained through the interaction of the hydrazone derivatives XI with mercaptoacetic acid. The obtained compounds have been characterized on the basis of their spectral (IR, PMR and Mass) data and elemental analysis. Most of these compounds have been found to exhibit good antibacterial and antifungal activities. The stability of some biologically active compounds towards gamma radiation have been investigated.