Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania - Concepedia

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Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania

10

Citations

12

References

2011

Year

José Ignacio Manzano, Luís Carvalho, Rigoberto Garcia-Hernandez, José A. Poveda, José A. Ferragut, Santiago Castanys, Francisco Gamarro

Journal of Antimicrobial Chemotherapy

Abstract

These findings suggest that Leishmania takes up tafenoquine by a diffusion process and that decreases in membrane sterol content may induce a decrease in drug uptake.

References

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Tafenoquine, an Antiplasmodial 8-Aminoquinoline, Targets <i>Leishmania</i> Respiratory Complex III and Induces Apoptosis Luís Carvalho, Juan R. Luque-Ortega, José Ignacio Manzano, Antimicrobial Agents and Chemotherapy Mitochondrial DysfunctionAntiparasitic AgentMalariaImmunologyCell Death	2010	93
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Filipin is a reliable in situ marker of ergosterol in the plasma membrane of germinating conidia (spores) of Penicillium discolor and stains intensively at the site of germ tube formation M.R. van Leeuwen, W. Smant, Wietse de Boer, Journal of Microbiological Methods BiologyPlasma MembranePathogenesisGerm Tube FormationPathology	2008	59
Antileishmanial and Antitrypanosomal Activities of the 8-Aminoquinoline Tafenoquine Vanessa Yardley, Francisco Gamarro, Simon L. Croft Antimicrobial Agents and Chemotherapy	2010	51
Restriction Endonuclease Analysis of Leishmania Kinetoplast DNA Characterizes Parasites Responsible for Visceral and Cutaneous Disease Peter R. Jackson, J. A. Wohlhieter, Joan E. Jackson, American Journal of Tropical Medicine and Hygiene	1984	48
Membrane sterol depletion impairs miltefosine action in wild-type and miltefosine-resistant Leishmania donovani promastigotes M. Saint-Pierre-Chazalet, M. Ben Brahim, Laurence Le Moyec, Journal of Antimicrobial Chemotherapy	2009	44
Sitamaquine Sensitivity in<i>Leishmania</i>Species Is Not Mediated by Drug Accumulation in Acidocalcisomes Carmen López-Martín, José M. Pérez‐Victoria, Luís Carvalho, Antimicrobial Agents and Chemotherapy	2008	39
Increased Glycolytic ATP Synthesis Is Associated with Tafenoquine Resistance in<i>Leishmania major</i> José Ignacio Manzano, Luís Carvalho, José M. Pérez‐Victoria, Antimicrobial Agents and Chemotherapy	2011	34

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