Concepedia

Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania

José Ignacio Manzano, Luís Carvalho, Rigoberto Garcia-Hernandez, José A. Poveda, José A. Ferragut, Santiago Castanys, Francisco Gamarro

Journal of Antimicrobial Chemotherapy · 2011 · 10 citations · 12 references

DOI

Abstract

These findings suggest that Leishmania takes up tafenoquine by a diffusion process and that decreases in membrane sterol content may induce a decrease in drug uptake.

References

12

Inactivation of the miltefosine transporter, LdMT, causes miltefosine resistance that is conferred to the amastigote stage of Leishmania donovani and persists in vivo

Karin Seifert, F. Javier Pérez‐Victoria, Marianne Stettler et al. · International Journal of Antimicrobial Agents · 2007 · 134 citations

, , +10

Randomized Trial of 3-Dose Regimens of Tafenoquine (WR238605) versus Low-Dose Primaquine for Preventing Plasmodium vivax Malaria Relapse

Douglas S. Walsh, Polrat Wilairatana, D. B. Tang et al. · Clinical Infectious Diseases · 2004 · 100 citations · Full text

Tafenoquine, an Antiplasmodial 8-Aminoquinoline, Targets <i>Leishmania</i> Respiratory Complex III and Induces Apoptosis

Luís Carvalho, Juan R. Luque-Ortega, José Ignacio Manzano et al. · Antimicrobial Agents and Chemotherapy · 2010 · 93 citations

, , +21

Alterations in membrane fluidity, lipid metabolism, mitochondrial activity, and lipophosphoglycan expression in pentamidine-resistant Leishmania

Mireille Basselin, Malka Robert-Géro · Parasitology Research · 1997 · 61 citations

, , +8

Filipin is a reliable in situ marker of ergosterol in the plasma membrane of germinating conidia (spores) of Penicillium discolor and stains intensively at the site of germ tube formation

M.R. van Leeuwen, W. Smant, Wietse de Boer et al. · Journal of Microbiological Methods · 2008 · 59 citations

, , +9