Differential Effects of Prostaglandin E₂-Sensitive Receptors on Contractility of Human Ocular Cells That Regulate Conventional Outflow

Abstract

Cell impedance positively correlates with cellular stiffness/contractility. Because EP2/4 receptors caused decreased cell stiffness in SC, but not in TM cells, both receptors appear to mediate IOP lowering via changes in SC cell stiffness in the conventional outflow pathway.