Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Andrew Fire, Siqun Xu, Mary K. Montgomery et al. · Nature · 1998 · 15.1K citations

Specific Genetic Interference, Natural Sciences, Genetics +9

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Sayda M. Elbashir, Jens Harborth, Winfried Lendeckel et al. · Nature · 2001 · 9.3K citations

Natural Sciences, Rna Splicing, Rna Biology +9

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

Brenda J. Reinhart, Frank J. Slack, Michael Basson et al. · Nature · 2000 · 4.9K citations

Developmental Timing, Developmental Biology, Genetics +6

Role for a bidentate ribonuclease in the initiation step of RNA interference

Emily Bernstein, Amy A. Caudy, Scott M. Hammond et al. · Nature · 2001 · 4.9K citations

Rna Interference, Genetics, Natural Sciences +12

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

Bruce Wightman, Ilho Ha, Gary Ruvkun · Cell · 1993 · 4.2K citations · Full text

Transcriptional Regulation, Developmental Biology, Developmental Genetics +9