Concepedia

Clinical pharmacokinetics of arecoline in subjects with Alzheimer's disease*

Sanjay Asthana, Nigel H. Greig, Harold W. Holloway, Kathleen C. Raffaele, Annamaria Berardi, Mark B. Schapiro, Stanley I. Rapoport, Timothy T. Soncrant

Clinical Pharmacology & Therapeutics · 1996 · 70 citations · 32 references

DOI

Abstract

Because optimal dose variation is due to differing plasma kinetics, the plasma arecoline level measured at a single infusion rate can be used to choose the optimal dose for memory enhancement in patients with Alzheimer's disease.

References

32

Clinical diagnosis of Alzheimer's disease

Guy M. McKhann, David A. Drachman, Marshall Folstein et al. · Neurology · 1984 · 27.8K citations · Full text

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

PJ Whitehouse, DL Price, R. G. Struble et al. · Science · 1982 · 3.6K citations

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

Elaine K. Perry, B. E. Tomlinson, G. Blessed et al. · BMJ · 1978 · 2K citations · Full text

Human Memory and the Cholinergic System

David A. Drachman · Archives of Neurology · 1974 · 1.4K citations

, , +19

Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation

Deborah C. Mash, Donna D. Flynn, Lincoln T. Potter · Science · 1985 · 700 citations

, , +17