Asymmetric Grignard Cross-Coupling Reaction Using Chiral Ligands Derived from Carbohydrates

Abstract

Abstract Chiral diphenylphosphine and diphenylphosphinite derivatives of carbohydrates such as d-glucose, d-galactose, and l-rhamnose were used as the ligand of metal catalysts for asymmetric Grignard cross-coupling reaction. Coupling of s-butylmagnesium bromide with bromobenzene was carried out in the presence of nickel or palladium chloride with the chiral ligand. The highest optical yield was observed when d-galactose ligand was used.