Giant-cell Granuloma of the Respiratory Tract (Wegener's Granulomatosis)

Abstract

This paper is based on a retrospective study of data from 10 patients who had in common an illness characterized by symptoms of progressive ulceration in the respiratory tract together with signs of widespread inflammatory disease. Histological examination of material from each case shows disseminated granulomata, most com- mon in the respiratory tract and kidneys, and widespread vascular lesions similar to polyarteritis nodosa. The name Wegener's granulomatosis has been applied to this syn-