Prolongation of Cardiac Allograft Survival by Inhibition of ERK1/2 Signaling in a Mouse Model

Abstract

Targeting ERK1/2 signaling results in suppression of alloimmune responses by an unique mechanism that involves Th1/Th2 skewing, suggesting a therapeutic potential of inhibition of ERK1/2 signaling for transplant rejection, particularly in combination with CsA.