Publication | Open Access
A Comparative Ultrastructural Study on Druginduced Proliferation of Smooth-surfaced Endoplasmic Reticulum in Hepatocytes
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Citations
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References
1971
Year
Comparative Ultrastructural StudyCellular PhysiologyOxidative StressCarbonyl MetabolismOther Cell OrganellesEndocytic PathwayHepatotoxicityBiochemistryLiver PhysiologyCell TraffickingHistopathologySer IncreaseProtein TransportDruginduced ProliferationPharmacologyCell BiologyDrug-induced Liver InjurySmooth-surfaced Endoplasmic ReticulumHepatologyNatural SciencesCyproterone AcetateIntracellular TraffickingCellular BiochemistryMetabolismMedicineExtracellular Matrix
In rats, administration of phenobarbital, 3-methylcholanthrene, spironolactone, cyproterone acetate or pregnenolone-16a-carbonitrile causes proliferation of the smooth-surfaced endoplasmic reticulum (SER) in hepatocytes, without producing marked changes in other cell organelles. The significance of this SER increase and its relationship to microsomal enzyme induction are discussed.
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