IMMUNE SUPPRESSION BY LYSOSOMOTROPIC AMINES AND CYCLOSPORINE ON T-CELL RESPONSES TO MINOR AND MAJOR HISTOCOMPATIBILITY ANTIGENS

Abstract

Lysosomotropic amines in combination with cyclosporine appear to be synergistic in the suppression of T-cell proliferation to MiHC and MHC. Use of chloroquine in combination with cyclosporine may result in improved control of GVHD.