C/EBP Homologous Binding Protein (CHOP) Underlies Neural Injury in Sleep Apnea Model

Abstract

Endogenous CHOP is necessary for LTIH-induced HIF-1α, Nox2 upregulation, and oxidative stress; CHOP influences LTIH-induced apoptosis in neurons and loss of neurons. Findings support the concept that minimizing CHOP may provide neuroprotection in OSA.