Cerebral Whipple's Disease with Negative Jejunal Histology

Abstract

ORGANIC psychosyndromes, paralysis of gaze, nystagmus and myoclonus may dominate the clinical appearance of Whipple's disease.1 2 3 The basis for these signs is infiltration of the cerebral gray matter by sickle-particle-containing (SPC) cells, as described by Sieracki4 and reviewed by others.1 2 3 Current observation of two patients has now revealed that Whipple's disease may also present itself with hypothalamic symptoms, which may even progress when there is no apparent involvement of the small intestine.Case ReportsCase 1. The clinical course of this patient has been reported up to 1975.1 Under treatment with penicillin, streptomycin, chloramphenicol and tetracycline, his arthritis, confusional states, . . .