IGF-I-Induced Phosphorylation of Connexin 43 by PKCγ: Regulation of Gap Junctions in Rabbit Lens Epithelial Cells

Abstract

PKCgamma mediated IGF-I-induced decreases in gap junctional communication through interaction with and phosphorylation of Cx43. IGF-I caused an increase in DAG, and this increased translocation of PKCgamma, whereas mobilization of calcium was not essential for IGF-I-stimulated translocation of PKCgamma.