Bioscience Biotechnology and Biochemistry · 1993 · 22 citations · 0 references
Life SciencesBiochemistryToxicologyBiochemical ToxicologyMycologyMycotoxicologyFungal BiochemistryFungal MetabolismFungal Natural Product BiosynthesisFungal Secondary MetabolitesMetabolite IdentificationMicrobial Metabolite ProductionBioactive Fungal MetabolitesFungal Bioactive CompoundsFungal Metabolite BiosynthesisPlant-associated Fungal MetabolitesStructure Elucidation Of Fungal MetabolitesToxic Mushroom Compounds
Malformins-produced by Aspergillus niger were separated by HPLC and subjected to structural determination. Amino acid analyses and mass spectra suggested that all of them structurally resembled cyclic pentapeptide malformin A1. Two-dimensional NMR experiments and MS/MS experiments led us to deduce cyclo-D-cysteinyl-D-cysteinyl-L-amino acid-D-amino acid-L-amino acid as being the essential structure of malformins.