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A Convenient Approach to the Synthesis of Deoxyribonucleoside-3′-hydrogen Phosphonates via Bis(1,1,1,3,3,3-hexafluoro-2-propyl) Phosphonate Intermediate
21
Citations
11
References
1988
Year
Bioorganic ChemistryEngineeringBiochemistryConvenient ApproachNatural SciencesChemical DerivativeOligonucleotidePhosphonate IntermediateOrganic ChemistryNew ReagentChemistryStereoselective SynthesisDeoxyribonucleoside-3′-hydrogen PhosphonatesAbstract TransesterificationSynthetic ChemistryBiomolecular EngineeringH-phosphonate Method
Abstract Transesterification of a new reagent, bis(1,1,1,3,3,3-hexafluoro-2-propyl)phosphonates was found to be very effective for the preparation of deoxyribonucleoside-3′-hydrogen phosphonates. The yields of deoxyribooligonucleotides by the H-phosphonate method on a solid support depended on the molar concentrations of the reacting species.
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