Measurement Characteristics of Anal Cytology, Histopathology, and High-Resolution Anoscopic Visual Impression in an Anal Dysplasia Screening Program

Abstract

These data suggest that the reproducibility of key screening measures is moderate at best but of similar magnitude to that of other studies of anal and cervical dysplasia screening. As candidate interventions to treat or prevent precursor lesions enter clinical development, standardization and improvement of measurement methods are essential.