PubMed · 2012 · 10 citations · 33 references
MedicineCancer BiologyOncologyMolecular OncologyNeoplasiaOncogenesKidney CancerRenal Cell CarcinomaRenal NeoplasmsTumor AntigensTumor Suppressor GenesTumor-associated AntigensAurora Kinase FunctionFuhrman GradingRenal Cell Carcinoma BiomarkersRenal Cell Carcinoma StagingRenal MalignancyRenal Tumor GradingTnm Staging SystemTumor Suppressor Pathways
We investigate the expression and localization of the tumor suppressor protein pVHL as well as the oncoprotein Aurora A kinase in kidney cancer. Both Aurora A kinase and pVHL protein status were evaluated using immunohistochemistry. The Aurora A expression is correlated with the Fuhrman grade and the TNM stage, while the pVHL expression is correlated with the capsule rupture and the TNM stage. Aurora A kinase expression increases in malignant tissue comparing to the non-malignant one. And there is a decrease in pVHL expression from the adjacent healthy tissues to the tumor`s ones. The two kinds of opposite tumor profiles display significant distribution difference according to TNM stages. It could be proposed that the absence of Aurora A protein associated with a strong expression of pVHL in clear cells kidney carcinoma are of good prognosis for the disease.
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Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene
Farida Latif, Kálmán Tory, James R. Gnarra et al. · Science · 1993 · 3K citations
Mutations of the VHL tumour suppressor gene in renal carcinoma
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