Cutaneous and Ocular Toxicology · 2013 · 149 citations · 22 references
Life SciencesDermatologyImmunologyClinical ImmunologyInflammationRheumatologyAutoimmune DiseasesAutoimmune Rheumatic DiseasesInflammatory BiomarkersInflammatory Skin DiseasesInflammatory Skin DisordersNeutrophil BiologyC-reactive Protein TestingCross-sectional Correlation StudyCross-sectional Population AnalysisDisease Severity IndexLeukocyte CountsNeutrophil-to-lymphocyte RatioPsoriatic DiseaseSystemic Inflammation Markers
OBJECTIVE: Psoriasis is a chronic systemic inflammatory disorder. The neutrophil to lymphocyte ratio (N/L ratio) has been used as a marker for systemic inflammatory status. In our study, we aimed to evaluate N/L ratio in patients with psoriasis. METHODS: This cross-sectional study population consisted of 138 patients with psoriasis and 120 age- and sex-matched control subjects. RESULTS: The patients had significantly higher neutrophil counts and lower lymphocyte counts than the controls. The N/L ratios and high sensitivity C reactive protein (hs-CRP) levels were also significantly higher in patients. The N/L ratios and hs-CRP levels were increasing with increasing in Psoriasis Area and Severity Index score. Furthermore, the N/L ratios and hs-CRP levels of patients were found to be positively correlated. CONCLUSIONS: Our data show that the N/L ratio to be a simple, inexpensive and easily assessable marker of systemic inflammation in patients with psoriasis.
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