Galectin-9 Attenuates Acute Lung Injury by Expanding CD14 ^– Plasmacytoid Dendritic Cell–like Macrophages

Abstract

Gal-9 attenuates ALI by expanding CD14(-)CD11b(+)Gr-1(+) pDC-like macrophages by preferentially suppressing macrophage functions to release proinflammatory cytokines through TLR4 and TLR2 down-regulation.