Circulating Biomarkers for Discrimination Between Aseptic Joint Failure, Low-Grade Infection, and High-Grade Septic Failure

Abstract

This is the first comprehensive prospective clinical study to our knowledge investigating the significance of a combined biomarker approach in differentiating between aseptic prosthesis loosening and low-grade joint infection. CRP plus IL-6 seems to be the most helpful combination for preoperative discrimination of aseptic loosening vs low-grade joint infection.