Concepedia

Phosphoregulation of MgcRacGAP in mitosis involves Aurora B and Cdk1 protein kinases and the PP2A phosphatase

Aminata Touré, Rym Mzali, Caroline Liot, Laetitia Seguin, Laurence Morin, Catherine Crouin, Ilin Chen-Yang, Yeou‐Guang Tsay, Olivier Dorseuil, Gérard Gâcon,

FEBS Letters · 2008 · 37 citations · 23 references

DOI Full text

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Concepts

Life SciencesBiochemistryMolecular BiologyCell SignalingMolecular Cell BiologySignal TransductionProtein Kinase CascadesProtein Phosphatase SignalingSmall Gtpase SignalingAurora Kinase FunctionAurora Kinase InhibitionProtein Phosphatase 2A RegulationProtein ScaffoldingRho Family Gtpase SignalingRho Family GtpasesSmall Rho Gtpase Signaling

Abstract

Structured summary: — MINT-6166761: Aurora B (uniprotkb:Q96GD4) phosphorylates (MI:0217) MgcRacGAP (uniprotkb:Q9H0H5) by protein kinase assay (MI:0424) — MINT-6166774: Cdk1 (uniprotkb:P06493) phosphorylates (MI:0217) MgcRacGAP (uniprotkb:Q9H0H5) by protein kinase assay (MI:0424) — MINT-6166653: PP2A (uniprotkb:P67775) dephosphorylates (MI:0203) MgcRacGAP (uniprotkb:Q9H0H5) by phosphatase assay (MI:0434) — MINT-6166710, MINT-6166727, MINT-6166735: MgcRacGAP (uniprotkb:Q9H0H5) physically interacts (MI:0218) with B56ε (uniprotkb:Q16537) by coimmunoprecipitation (MI:0019) — MINT-6166691: B56ε (uniprotkb:Q16537) physically interacts (MI:0218) with MgcRacGAP (uniprotkb:Q9H0H5) by far western blotting (MI:0047) — MINT-6166556: MgcRacGAP (uniprotkb:Q9H0H5) physically interacts (MI:0218) with B56ε (uniprotkb:Q16537) by two-hybrid (MI:0018) — MINT-6166634: MgcRacGAP (uniprotkb:Q9H0H5) physically interacts (MI:0218) with Ect2 (uniprotkb:Q9H8V3) by coimmunoprecipitation (MI:0019) — MINT-6166596: MKLP-1 (uniprotkb:Q02241) physically interacts (MI:0218) with B56ε (uniprotkb:Q16537) , MgcRacGAP (uniprotkb:Q9H0H5), PP2A (uniprotkb:P67775) bycoimmunoprecipitation (MI:0019)