SERIAL ANGIOGRAPHY IN CANINE RENAL ALLOGRAFTS

Abstract

Serial studies of the vascular tree of canine renal autografts, unmodified first-set allografts, and a second-set allograft were performed. Thorotrast was utilized so as to allow visualization of both the arterial and venous beds. Serial determination of scrum creatinine, BUN and effective renal plasma, flow were obtained. Histologic correlation of radiographic abnormalities in the venous tree was made. Attenuation, truncation and separation characterized changes in the arterial tree of the first-set allografts. Similar, less striking changes occurred in the veins. Intraluminal venous filling defects occurred prior to other radiographic and laboratory abnormalities. Subintimal round cell infiltrates, possibly related to the venous vasa vasorum or perivenous lymphatics, appear to be the basis for these defects.