Requirement of <scp>M</scp>y<scp>D</scp>88 and <scp>F</scp>as pathways for the efficacy of allergen‐free immunotherapy

Abstract

This study provides new insights on the mechanisms of allergen-free immunotherapy by showing that both DNA-HSP65 and CpG/CFP downregulated house dust mite-induced allergic airway inflammation via distinct pathways that involve not only induction of mycobacterial-specific adaptive responses but also signaling via MyD88 and Fas molecules.