A Concise Ex Chiral Pool Approach to Novel Bidentate Camphane Phosphane Ligands

Abstract

The bidentate hydroxy phosphane 20 and the phosphane phosphinite 21, each bearing a camphane skeleton, were prepared in five and six steps (52% and 28% yield), respectively, from (1S)-(+)-camphorsulfonic acid 8 via the triethylsilyl-protected iodide 17 as a key intermediate. An X-ray crystal structure was obtained for 21.