Transcatheter Hemostasis of Gastrointestinal Bleeding Using Modified Autogenous Clot

Abstract

Clinical and laboratory experience with clot additives and with the use of modified autogenous clot as an agent for transcatheter hemostasis is described. Oxycel (oxidized cellulose) produces a highly occlusive, relatively stable, firm clot and is eventually absorbed. It offers a firm matrix for clot formation, promotes coagulation despite a variety of deficient clotting factors, increases clot durability, and delays clot lysis. All nine patients in the clinical study showed immediate cessation of gastrointestinal bleeding. Two instances of transient duodenal infarction, attributable to the use of clots, indicate that the method is not without some risk.