Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6‐PSD‐95‐MLK3 signaling module in KA‐induced seizure

Abstract

Taken together, we demonstrate that coactivation of the inhibitory GABA receptors can attenuate the excitatory JNK3 apoptotic signaling pathway via inhibiting the increased assembly of the GluR6-PSD-95-MLK3 signaling module induced by KA. This provides a new insight into the therapeutic approach to epileptic seizure.