Immunology and Cell Biology · 1986 · 10 citations · 0 references
Veterinary MedicineImmunologyInfectious DiseasesInfectious Disease PathologyParasite ImmunologyParasitologyHelminth ImmunologyHelminth PathogenesisHost-parasite Immune InteractionsParasite AntigensParasitic Disease PathogenesisParasitic PathogenesisHost Immunity To ParasitesHost Resistance To ParasitesHost-parasite ImmunityIn Vivo Resistance AssaysParasitic Helminth ImmunologyParasitic Infection ImmunityResistance Mechanisms In ParasitesResistance To Parasitic Infection
Mice of the strain 129/J bred at this Institute (WEHI 129/J) were exposed once or repeatedly to cercariae of Schistosoma mansoni and worm burdens determined. In keeping with reports of S. japonicum infection in these mice, a high level of resistance was recorded. Radio-labelled extracted antigens of S. mansoni adult worms were reacted with sera from exposed 129/J mice and infected BALB/c mice. Immunoprecipitated antigens preferentially recognized by antibodies in 129/J mice include proteins of Mr 99,000 and 21,000. Whether responses to these antigens are a cause or a consequence of resistance remains to be established.