Cardiorespiratory and Spinal Cord Blood Flow Effects of Intrathecal Neostigmine Methylsulfate, Clonidine, and Their Combination in Sheep

Abstract

Intrathecal neostigmine alone or in combination with clonidine does not reduce spinal cord blood flow, an important preclinical toxicity issue. These results provide additional support for initial clinical trials of intrathecal neostigmine for analgesia.