THE PATHOLOGICAL EFFECTS UPON RATS OF EXCESS IRRADIATED ERGOSTEROL 1

Abstract

The remarkable power of irradiated ergosterol to prevent or to cure rickets in infants and aimals, first demonstrated for rats by Rosenheim and Webster (1) and Windaus and Hess (2) (3) has been amply con- firmed (4) (5) (6) (7). For rats, 0.000,1 mgm. (8) or less (5) (9) and for infants 2 to 4 mgm. (5) (10) have proved adequate for cure. If such small amounts produce such striking therapeutic results, the question arises, what are the changes brought about by larger doses.