The Enantioface-differentiating Methylation of the <i>N</i>-Benzylidene-<scp>Dl</scp>-phenylalanine Methyl Ester in the Presence of Chiral Lithium Amides

Abstract

Abstract The asymmetric methylation of the N-benzylidene-Dl-phenylalanine methyl ester was carried out in the presence of lithium salts of secondary amines derived from (S)-proline. The lithium amides of poly(imino-1-isobutylethylene) and its corresponding low-molecular-weight model compound, derived from (S)-leucine, were similarly used in order to examine the polymer effects with regard to the stereoselectivity.