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Value of p16INK4a in the Pathology of Invasive Penile Squamous Cell Carcinomas

DOI

113

Citations

0

References

2011

Year

Antonio L. Cubilla, Belén Lloveras, María Alejo, Omar Clavero, Alcides Chaux, Elena Kasamatsu, Núria Monfulleda, Sara Tous, Laia Alemany, Joellen Klaustermeier,
The American Journal of Surgical Pathology

Abstract

p16(INK)⁴(a) overexpression was found to be a reliable marker for HR-HPV and a helpful tool in the differential diagnosis of low-grade verruciform and high-grade solid penile tumors. SCC variants depicting basaloid features were more likely to be HPV and p16(INK)⁴(a) positive than low-grade, keratinizing lesions. We also observed a tendency toward HPV positivity in high-grade nonbasaloid tumors. Our results indicated a concordance between HPV and p16(INK)⁴(a) status and this observation may have diagnostic and prognostic implications.