Urinary Excretion of N-Methylhistamine as a Marker of Disease Activity in Inflammatory Bowel Disease

Abstract

Urinary excretion of the histamine metabolite UMH is enhanced in IBD. It appears to represent an integrative parameter to monitor clinical and endoscopic disease activity in IBD, which appears to be influenced most likely by mediators released from histamine-containing cells, such as intestinal mast cell subtypes.