Distinct clonotypic Epstein–Barr virus-induced fatal lymphoproliferative disorder in a patient with wiskott-aldrich syndrome

Abstract

The EBV-induced fatal LPD in a patient with WAS showed the characteristic clonotype, polyclonal immunoglobulin gene rearrangement, and monoclonal EBV terminal configuration. Furthermore, EBV termini in each lesion varied in size. This particular clonotype implicates several unique pathogenetic mechanisms for clonal proliferation of EBV-induced LPD.