Interactive Role of Protein Kinase C-δ with Rho-Kinase in the Development of Cerebral Vasospasm in a Canine Two-Hemorrhage Model

Abstract

The development of cerebral vasospasm after SAH (on day 4) is caused by at least two mechanisms: one involves MLC20 phosphorylation mediated by the inhibition of MLC20 phosphatase by Rho-kinase, and the other CaD phosphorylation mediated by the activation of PKC-delta by Rho-kinase, which results in the alleviation of the inhibition by CaD of myosin Mg2+-ATPase activity.