Sequential estimation of quantal response curves: A new method of estimation

Abstract

This paper studies methode given by Wetherill (1963) for estimating general percentage points of a quantal response curve. A new method of estimation is proposed which is both simple to compute and highly efficient. The use of this with the Up and Down Transformed Reaponse Rule (UDTR) is investigated, by exact calculation of probability distributions and by empirical sampling trials. The use of the UDTR to estimate the slope of a response curve is outlined.