Microwave-assisted neat reaction technology for the synthesis of s-triazolo[3,4-b]-1,3,4-thiadiazines

Abstract

An expeditious, solvent-free, and high yielding synthesis of nitrogen containing heterocycles from 1,2,4-s-triazole, benzoin, chloroacetic acid or phenacyl bromide under microwave irradiation is described. This improved greener synthetic methodology provides a simple and straightforward one-pot approach for the synthesis of a variety of heterocycles.