Alterations with age in peripheral blood lymphocyte subpopulations and cytokine synthesis in beagles

Abstract

Decreases of naive CD4⁺ and naive CD8⁺ T cells may be related to age-related immunosenescence in dogs. With regard to cytokine production, leukocyte IL-4 and IL-10 mRNA levels did not change with age, whereas IL-2, IL-2Rα, and IL-2Rγ mRNA levels decreased with age. These altered cytokine mRNA expression patterns may contribute to decreased naive T-cell function(s) with aging.