Ligand-mediated addition of organometallic reagents to azomethine functions

Abstract

Despite the enormous progress made in the asymmetric addition of nucleophiles to prochiral carbonyl compounds for the preparation of chiral alcohols, the corresponding study of enantioselective conversion of prochiral azomethine functions to chiral amines remains a relatively undeveloped area of research. This account reviews the current state of this new field of investigation.