Timing of Myocardial <i>Trpm7</i> Deletion During Cardiogenesis Variably Disrupts Adult Ventricular Function, Conduction, and Repolarization

Abstract

Trpm7 is dispensable in adult ventricular myocardium under basal conditions but is critical for myocardial proliferation during early cardiogenesis. Loss of Trpm7 at an intermediate developmental time point alters the myocardial transcriptional profile in adulthood, impairing ventricular function, conduction, and repolarization.