Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging

TLDR

We have labeled abstract lines. Let's aggregate per label. Purpose: lines with Purpose: first line: "[Purpose, Mechanism] Abstract Methods are presented to map complex fiber architectures in tissues by imaging the 3D spectra of tissue water diffusion with MR." So Purpose content: "Abstract Methods are presented to map complex fiber architectures in tissues by imaging the 3D spectra of tissue water diffusion with MR." Also maybe other lines with Purpose? None else. Background: lines with Background: second line: "[Background] First, theoretical considerations show why and under what conditions diffusion contrast is positive." and last background: "[Background] Finally, the relation between the presented model‑free imaging technique and other available diffusion MRI schemes is discussed." So background content: combine: "First, theoretical considerations show why and under what conditions diffusion contrast is positive.

Abstract

Abstract Methods are presented to map complex fiber architectures in tissues by imaging the 3D spectra of tissue water diffusion with MR. First, theoretical considerations show why and under what conditions diffusion contrast is positive. Using this result, spin displacement spectra that are conventionally phase‐encoded can be accurately reconstructed by a Fourier transform of the measured signal's modulus. Second, studies of in vitro and in vivo samples demonstrate correspondence between the orientational maxima of the diffusion spectrum and those of the fiber orientation density at each location. In specimens with complex muscular tissue, such as the tongue, diffusion spectrum images show characteristic local heterogeneities of fiber architectures, including angular dispersion and intersection. Cerebral diffusion spectra acquired in normal human subjects resolve known white matter tracts and tract intersections. Finally, the relation between the presented model‐free imaging technique and other available diffusion MRI schemes is discussed. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.