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Two-Step, Stereoselective Hydrazidoarylation of 1,3-Cyclopentadiene
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2002
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Cross-coupling ReactionEngineeringHeterocyclicAlkene MetathesisFormal HydrazidoarylationOrganic ChemistryOrganometallic CatalysisCatalysisSodium FluorideChemistryHeterocycle ChemistryStereoselective SynthesisPharmacologyEnantioselective SynthesisCn BondStereoselective Hydrazidoarylation
The product of a formal hydrazidoarylation of cyclopentadiene was obtained for the first time by palladium-catalyzed reaction of diaza[2.2.1]bicyclic alkenes with aryl halides in the presence of triphenylarsane, sodium fluoride, and formic acid under stereoselective cleavage of a CN bond (see scheme).