Thiopurine S‐methyltransferase (TPMT) polymorphisms in children with acute lymphoblastic leukemia, and the need for reduction or cessation of 6‐mercaptopurine doses during maintenance therapy: The Polish multicenter analysis

Abstract

The results indicate that TPMT genotype influences the safety and efficacy of ALL treatment and genotype information may therefore be useful for optimizing 6-MP therapy.