Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

Bernard Fisher, Joseph P. Costantino, D. Lawrence Wickerham et al. · JNCI Journal of the National Cancer Institute · 1998 · 5.5K citations · Full text

Medicine, Oncology, Preventive Medicine +15

Two distinct estrogen‐regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

Philippe Kastner, A. Krust, Bernard Turcotte et al. · The EMBO Journal · 1990 · 1.5K citations · Full text

Life Sciences, Endocrinology, Molecular Biology +14

Active Tamoxifen Metabolite Plasma Concentrations After Coadministration of Tamoxifen and the Selective Serotonin Reuptake Inhibitor Paroxetine

Vered Stearns · JNCI Journal of the National Cancer Institute · 2003 · 849 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Progesterone Receptor Status Significantly Improves Outcome Prediction Over Estrogen Receptor Status Alone for Adjuvant Endocrine Therapy in Two Large Breast Cancer Databases

Valérie‐Jeanne Bardou, Grazia Arpino, Richard Elledge et al. · Journal of Clinical Oncology · 2003 · 757 citations

Medicine, Endocrinology, Oncology +17

Comprehensive Evaluation of Tamoxifen Sequential Biotransformation by the Human Cytochrome P450 System in Vitro: Prominent Roles for CYP3A and CYP2D6

Zeruesenay Desta, Bryan A. Ward, Nadia Soukhova et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 645 citations

Medicine, Biochemistry, Pharmacology +17