Testosterone-Induced Remission in Aplastic Anemia of Both Acquired and Congenital Types

Abstract

THE term aplastic anemia may have various meanings in different clinics. Occasionally, it is used for a condition in which there is peripheral pancytopenia but a normally cellular or even hypercellular bone marrow. Such a state may be associated with a good prognosis even without therapy. As described in this report, aplastic anemia is a physiologic and anatomic failure of the bone marrow, with marked decrease or absence of blood-forming elements in the marrow, peripheral pancytopenia and no splenomegaly, hepatomegaly or lymphadenopathy.§ Most children with this disease die from anemia, hemorrhage or infection, despite treatment with antimicrobial drugs, corticosteroids and . . .