Publication | Open Access
Reliable set-up for in-loop 11C-carboxylations using Grignard reactions for the preparation of [carbonyl-11C]WAY-100635 and [11C]-(+)-PHNO
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Citations
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References
2013
Year
Combinatorial ChemistryReliable Set-upBioorganic ChemistryEngineeringOrganic ChemistryChemistryNovel OrganocatalystsGeneralized In-loop SynthesisIn-loop 11C-carboxylationsOrganometallic CatalysisHigh ReliabilityCross-coupling ReactionBiochemistryGeneral ApplicabilityCatalysisAsymmetric CatalysisBiomolecular EngineeringNatural SciencesSynthetic ChemistryGrignard Reactions
Aim of this work was the implementation of a generalized in-loop synthesis for (11)C-carboxylations and subsequent (11)C-acylations on the TRACERlab FxC Pro platform. The set-up was tested using [carbonyl-(11)C]WAY-100635 and, for the first time, [(11)C]-(+)-PHNO. Its general applicability could be demonstrated and both [carbonyl-(11)C]WAY-100635 and [(11)C]-(+)-PHNO were prepared with high reliability and satisfying outcome.
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