The Nephron journals/Nephron journals · 2008 · 43 citations · 0 references
MedicineImmunologyNephrologyCell ProliferationRenal PathologyRenal PathophysiologyGlomerular PathophysiologyImmune-mediated Renal DiseaseNephrotic SyndromeRenal DiseaseRenal ImmunopathologyRenal PhysiologyGlomerular Basement Membrane AntigensLymphocyte PhysiologyProteinuria ReductionRenal Organ CultureT Cell-mediated Renal Injury
The effect on the kidney capillaries of T lymphocyte culture supernatants from patients with minimal change nephrotic syndrome was studied by infusion into the left renal artery of rats. The supernatants of T lymphocyte cultures from nephrotic patients induced significant proteinuria and a reduction of anionic sites in the glomerular basement membrane of the kidneys in the rats. These changes were not produced in rats receiving equivalent supernatants from healthy controls.